发育性口吃儿童的脑血流异常
Wanqing Liu1,2, Dan Ma2,3, Chuanlong Cao4
1Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China.
Pediatric research
|June 24, 2024
概括
吃的孩子在特定的大脑区域的脑血流 (CBF) 发生变化. 小脑和尾环中的CBF降低,以及前额环中的CBF增加,可能有助于早期识别口吃.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 语音和语言障碍 语音和语言障碍
背景情况:
- 口影响5%的儿童,其神经基础不明.
- 识别神经成像生物标志物对于早期检测和干预至关重要.
- 静止状态大脑血流 (CBF) 是发育性口吃的一个潜在生物标志物.
研究的目的:
- 研究发育性口吃儿童与健康对照儿童之间静止状态CBF的差异.
- 为了确定口的潜在神经成像生物标志物.
- 探索CBF异常和口吃严重程度之间的相关性.
主要方法:
- 使用脉冲动脉旋标记磁共振成像来量化CBF.
- 在35名发育性口吃的儿童和27名健康对照中比较正常化的CBF.
- 评估了异常CBF和口吃的临床指标之间的相关性.
主要成果:
- 吃的儿童在小脑 (第六叶片) 和回 (上部) 中表现出正常化CBF的下降.
- 在口吃组中,在额头 (中部上部,直肠,背侧上部) 观察到增加的正常化CBF.
- 在左小脑叶VI和左上尾环中的异常CBF与口吃的严重程度呈正相关性.
结论:
- 吃的孩子表现出明显的CBF变化的模式,其中小脑/尾区域的减少和额头区域的增加.
- 在左小脑叶VI和左上尾环中CBF降低与更严重的口吃有关.
- CBF的变化可以作为新的神经成像生物标志物,用于早期检测和理解发育性口吃.
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