伴随性疾病对牛皮关节炎患者报告结果的影响:单一中心队列研究
Grzegorz Biedroń1,2, Mateusz Wilk3, Jarosław Nowakowski4,3
1Department of Rheumatology and Immunology, Jagiellonian University Medical College, Jakubowskiego 2, Kraków, Poland. grzegorz.biedron@uj.edu.pl.
伴随性疾病显著恶化了牛皮关节炎 (PsA) 患者的生活质量. 心血管疾病和精神障碍对PsA患者的身体功能,心理健康和社会福祉产生负面影响.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 患者报告的结果
背景情况:
- 牛皮关节炎 (PsA) 经常与其他疾病 (共同疾病) 发生,可能会使患者的健康状况恶化.
- 患者报告的结果 (PROs) 对于评估PsA患者所经历的疾病负担至关重要.
研究的目的:
- 调查伴随性疾病对成年患者诊断为牛皮关节炎 (PsA) 的特定PRO的影响.
主要方法:
- 一项横截面的观察性研究包括267名符合CASPAR标准的成年PsA患者.
- 收集的数据包括并发症和PRO,如健康评估问卷 (HAQ),多维健康评估问卷 (MDHAQ) 和36项简短形式健康调查 (SF-36).
- 标准的统计方法用于数据分析.
主要成果:
- 多种病症 (50.2%的患者) 与SF-36的身体疼痛,身体功能和角色物理领域的得分降低有关.
- 心血管疾病 (CVD) 与较差的MDHAQ功能评分相关.
- 精神障碍对多个SF-36维度产生了不利影响,包括心理健康,活力,一般健康,社会功能和角色情感.
结论:
- 多种病症显著损害了PsA患者的身体生活质量 (QoL).
- 心血管疾病和精神障碍对功能能力和精神/社会生活质量分别产生负面影响.
- 临床医生和研究人员在评估PsA的PRO时必须考虑并发症的影响.
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