青少年使用抗抑郁药的糖尿病发病率:系统性审查和元分析
Fatemeh Movahed1, Ehsan Heidari2, Dina Sadeghi3
1Tehran University of Medical Sciences, Tehran, Iran.
European child & adolescent psychiatry
|June 24, 2024
概括
青少年使用抗抑郁药与患2型糖尿病的风险更高有关,特别是服用更高剂量. 这凸显了使用这些药物的年轻患者血糖水平监测的必要性.
科学领域:
- 内分泌学和代谢性疾病.
- 精神病学和心理健康 精神病学和心理健康
- 临床药理学 临床药理学
背景情况:
- 青少年和年轻人中抗抑郁药的使用增加与这些人口中2型糖尿病 (T2D) 风险的增加相吻合.
- 抗抑郁药使用与年轻人群中T2D发病率之间的关联尚未得到充分证实.
研究的目的:
- 研究抗抑郁药使用与青少年和年轻成年人2型糖尿病发病率之间的关系.
- 量化与抗抑郁药治疗相关的糖尿病风险在这个年龄组.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA和Cochrane指南.
- 在PubMed,Scopus,Embase和Web of Science数据库中进行全面的文献搜索.
- 包括来自北美,欧洲和亚洲的六项具有高质量的研究,参与者数量大 (16,470至1,582,914人).
主要成果:
- 在抗抑郁药的使用和糖尿病发病之间发现了显著的关联 (10例/1000次观察,p < 0.01).
- 服用高剂量抗抑郁药的青少年与不使用者或低剂量使用者相比,患糖尿病的风险增加了62% (RR = 1.67,95% CI 1.19-2.35).
- 研究质量高 (纽卡斯尔-太华平均得分为7.66),经过敏感性分析证实了强有力的研究结果,尽管存在一些异质性.
结论:
- 青少年使用抗抑郁药与患2型糖尿病的风险增加有显著关联.
- 较高的抗抑郁剂剂量与糖尿病发病风险更高相关.
- 建议使用抗抑郁药的青少年进行常规血糖监测,需要进一步研究机制和长期影响.
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