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Updated: Jun 23, 2025

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优化深度突变扫描工作流程,以提高对蛋白质-蛋白质相互作用突变影响的量化

Alexandra M Bendel1,2, Kristjana Skendo3, Dominique Klein1

  • 1Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.

BMC genomics
|June 24, 2024
PubMed
概括

深度突变扫描 (DMS) 试验可能存在技术缺陷,扭曲结果. 将DNA量和收获时间等参数的非线性影响降到最低,可以改善蛋白质功能分析.

关键词:
深度突变扫描 进行深度突变扫描.高通量测试试验 高通量测试试验方法优化方法优化非线性是非线性的.蛋白质与蛋白质之间的相互作用

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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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