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表皮生长因子受体作为口腔网状和侵蚀性平坦的蛋白质标记物的表达

Forooz Keshani¹, Neda Kargahi¹, Mohammad Hossein Nikbakht²

¹Department of Oral and Maxillofacial Pathology, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

BMC oral health

|June 24, 2024

概括

表皮生长因子受体 (EGFR) 表达在侵蚀性口腔平坦 (OLP) 中明显高于健康对照组. 这一发现突出了EGFR的重点.

科学领域:

口腔病理学口腔病理学
在瘤学瘤学.
免疫组织化学免疫组织化学

背景情况:

口腔平坦 (OLP) 是一种具有前恶性潜力的慢性炎症状况.
表皮生长因子受体 (EGFR) 与瘤发生有关,在口腔癌中经常过度表达.
之前关于OLP中EGFR表达的研究已经产生了相互矛盾的结果.

研究的目的:

为了比较EGFR作为网状OLP和侵蚀性OLP中的蛋白质标记物的表达.
评估与对照组相比,OLP病变中的EGFR表达.

主要方法:

一项描述性-分析性横截面研究涉及39个嵌入的组织样本 (15个网状OLP,16个侵蚀性OLP,8个对照).
进行了免疫组织化学染色以检测EGFR表达.
样品由两名大面病理学家分析,以确定染色细胞的百分比,强度,模式和位置.

主要成果:

在侵蚀性OLP和对照组之间发现了EGFR染色细胞平均百分比的显著差异 (P=0.035).
在侵蚀性OLP和网状OLP之间 (P=0.213) 或在网状OLP和对照之间 (P=0.137) 没有观察到EGFR染色百分比的显著差异.
在三组染色强度,图案或位置上没有发现显著差异.

结论:

与健康的口腔粘膜相比,侵蚀性OLP表现出明显更高的EGFR表达.
EGFR可能在侵蚀性OLP的进展中发挥作用,将其与网状形式和健康组织区分开来.
需要进一步的研究来阐明EGFR在OLP病变和恶性转变中的特定作用.

关键词:

欧洲农业基金会 (EGFR) 是一个基金.皮质生长因子受体表皮生长因子受体免疫组织化学免疫组织化学口腔平坦的类.

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