空气污染物与早产和血液常规变化的关系在典型的河谷城市
BMC public health
|June 24, 2024
概括
暴露于空气污染,包括PM2.5和PM10,增加了早产的风险. 空气污染物也会影响孕妇的白细胞和红细胞等血细胞计数.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 毒理学 毒理学 毒理学
背景情况:
- 空气污染是一个日益严重的全球性问题,对母亲和儿童的健康有重大影响.
- 早产仍然是全球新生儿死亡率和发病率的主要原因.
- 了解各种空气污染物对怀孕结果的具体影响,对于公共卫生干预至关重要.
研究的目的:
- 调查暴露于常见空气污染物 (PM2.5,PM10,SO2,NO2,CO,O3) 和早产之间的关系.
- 探索空气污染物对早产的短期,长期,滞后和累积影响.
- 检查空气污染物暴露与母亲血细胞计数变化之间的关系.
主要方法:
- 利用了来自延安市 (2017-2020) 的每日空气污染物度数据和气象信息.
- 应用条件后勤回归来分析空气污染物和早产之间的联系,包括滞后和累积效应.
- 采用多重和阶段线性回归来评估污染物对血液参数的影响.
主要成果:
- 长期暴露于PM2.5,PM10,SO2,NO2和CO与早产风险的增加显著相关.
- PM2.5,PM10,SO2,NO2和CO的滞后和累积效应也与早产有关.
- 空气污染物与白细胞,单细胞,基细胞,红细胞和hs-CRP的变化相关,但不是CRP.
结论:
- 暴露于环境空气污染物是早产的可证明风险因素.
- 暴露于空气污染物与孕妇关键血细胞计数和炎症标志物的改变有关.
- 研究结果强调,需要制定策略来减轻怀孕期间的空气污染暴露,以改善分娩结果.
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