Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Olfaction01:25

Olfaction

44.3K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.3K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.3K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.3K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.2K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

521
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
521
Neurotransmitters01:31

Neurotransmitters

866
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
866

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Association between Fast Food Outlets and Overweight in Adolescents Is Confounded by Neighbourhood Deprivation: A Longitudinal Analysis of the Millennium Cohort Study.

International journal of environmental research and public health·2021
Same author

24-Hour Physical Behavior Balance for Better Health for All: "The Sweet-Spot Hypothesis".

Sports medicine - open·2021
Same author

Is Olfactory Impairment Associated With 10-year Mortality Mediating by Neurodegenerative Diseases in Older Adults? The Four-Way Decomposition Analysis.

Frontiers in public health·2021
Same author

Effects of Motion-Relevant Knowledge From Unlabeled Video to Human-Object Interaction Detection.

IEEE transactions on neural networks and learning systems·2021
Same author

Higher one-year achievement rate of serum phosphate associated with lower cardiovascular mortality in hemodialysis patients.

BMC nephrology·2021
Same author

Prognostic validity of the American joint committee on cancer eighth edition staging system for well-differentiated pancreatic neuroendocrine tumors.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2021
Same journal

The predictive power of neuropsychological measures in MCI: early detection of dementia conversion.

Frontiers in aging neuroscience·2026
Same journal

Age-associated neuronal micronuclei formation and transfer to microglia.

Frontiers in aging neuroscience·2026
Same journal

Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer's disease mice by remodeling gut microbiota and host serum metabolites.

Frontiers in aging neuroscience·2026
Same journal

Behind the scenes of a 7T MRI clinical study in Alzheimer's disease: challenges and recommendations for future research.

Frontiers in aging neuroscience·2026
Same journal

Striatal functional connectivity alterations in mild cognitive impairment subtypes defined by CSF A/T biomarkers.

Frontiers in aging neuroscience·2026
Same journal

State sensitivity and five-year longitudinal stability of resting-state EEG biomarker candidates in healthy adults.

Frontiers in aging neuroscience·2026
查看所有相关文章

相关实验视频

Updated: Jun 23, 2025

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.0K

血清TRPA1调解了嗅觉功能和认知功能之间的关联.

Xiaoniu Liang1,2,3, Zhenxu Xiao1,2,3, Jie Wu1,2,3

  • 1Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Frontiers in aging neuroscience
|June 25, 2024
PubMed
概括
此摘要是机器生成的。

这项研究表明,TRPA1通道调解了中国老年人嗅觉识别和认知功能之间的联系. 在认知障碍患者中观察到更高的TRPA1水平,这表明TRPA1在认知衰退中的作用.

关键词:
在 TRPA1 中,认知功能 认知功能年长的老人老年人老年人.调解分析 调解分析嗅觉识别 嗅觉识别是一种识别方式.

更多相关视频

Assessment of Social Transmission of Food Preferences Behaviors
04:56

Assessment of Social Transmission of Food Preferences Behaviors

Published on: January 25, 2018

8.0K
Constructing an Olfactometer for Rodent Olfactory Behavior Studies Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
08:36

Constructing an Olfactometer for Rodent Olfactory Behavior Studies Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: April 11, 2025

199

相关实验视频

Last Updated: Jun 23, 2025

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.0K
Assessment of Social Transmission of Food Preferences Behaviors
04:56

Assessment of Social Transmission of Food Preferences Behaviors

Published on: January 25, 2018

8.0K
Constructing an Olfactometer for Rodent Olfactory Behavior Studies Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
08:36

Constructing an Olfactometer for Rodent Olfactory Behavior Studies Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: April 11, 2025

199

科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 生物化学 生物化学

背景情况:

  • 嗅觉功能障碍与老年人的认知能力下降有关.
  • 在这种关联中,短暂受体潜在通道亚家族A成员1 (TRPA1) 的作用仍未研究.
  • 研究TRPA1的调解效果对于理解认知衰老至关重要.

研究的目的:

  • 评估TRPA1对嗅觉功能和认知功能之间的关联的调解效应.
  • 探索TRPA1水平与中国老年人的认知状态之间的关系.
  • 识别潜在的认知障碍生物标志物.

主要方法:

  • 招募了121名认知障碍 (CI) 的参与者和135名正常认知 (NC) 的参与者.
  • 嗅觉识别使用嗅探棒选试验12 (SSST-12) 进行评估.
  • 血清TRPA1水平通过酶相关免疫吸收试验量化,并进行中介分析.

主要成果:

  • 与NC组相比,CI组的血清TRPA1升高的患病率 (58.7%) 高于NC组 (42.2%) (p=0.0086).
  • 调解分析证实TRPA1部分调解SSST-12分数与迷你精神状态检查 (MMSE) 绩效之间的关联.
  • 此外,TRPA1还部分调解了薄荷识别和MMSE得分之间的关系.

结论:

  • 在老年人中,TRPA1在嗅觉功能和认知功能之间的关系中发挥着重要的调解作用.
  • 这些发现突出了TRPA1作为潜在的因素,将嗅觉障碍和认知能力下降联系起来.
  • 需要进一步的研究来阐明TRPA1在认知恶化中的精确机制.