针对儿科多药耐药结核病的贝达基林纳米乳液的开发:辅助剂选择和预配方研究

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Taiwo Oreoluwa Ajayi¹, Madan Sai Poka¹, Bwalya Angel Witika¹

¹Department of Pharmaceutical Science, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Frontiers in medical technology

|June 25, 2024

概括

预制研究成功地确定了贝达奎林 (BDQ) 纳米乳液的最佳辅助剂. 这些发现对于开发稳定,自我乳化药物输送系统至关重要.

科学领域:

制药科学制药科学
药物输送系统药物输送系统

背景情况:

预制研究对于成功开发纳米乳液至关重要,涉及药物结构,辅助剂选择,成分和物理属性.
贝达基林 (BDQ) 是一种关键药物,其成功制成纳米乳液需要仔细的预制工作.

研究的目的:

评估贝达基林 (BDQ) 的特性,并确定适合自乳化BDQ载纳米乳液的辅助剂.
定义稳定的纳米乳液配方所需的预配方参数.

主要方法:

用验证的HPLC方法在各种油中确定BDQ的和溶解度.
福里埃变换红外光谱法 (FTIR) 评估了BDQ辅助剂的兼容性.
用于构建相位图和描述乳化行为的水定位方法.

主要成果:

BDQ在橄油中溶解度最高 (3.45 ± 0.041 毫克/毫升).
阶段图显示了Winsor产品的形成,证实了成功的乳化.
FTIR分析证实BDQ与选定的辅助剂之间没有相互作用.

结论:

预制研究成功地确定了BDQ纳米乳液的兼容辅助剂.
已确定的预制参数对于开发自乳化BDQ装载纳米乳液至关重要.
这项工作为使用贝达奎林的先进药物输送系统奠定了基础.

关键词:

药物输送是药物输送的过程.纳米乳液 (NE) 是一种纳米乳液.儿科儿科儿科预制的兼容性预制的兼容性溶解性研究溶解性研究结核病是一种肺结核病.

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