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Updated: Jun 23, 2025

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
06:38

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

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反向工程神经元类型特定和类型直角拼接调节网络使用单细胞转录组

Daniel F Moakley1,2,3, Melissa Campbell1,2,3,4, Miquel Anglada-Girotto1,5

  • 1Department of Systems Biology, Columbia University, New York, NY 10032, USA.

bioRxiv : the preprint server for biology
|June 25, 2024
PubMed
概括

研究人员在133种小鼠神经元类型中绘制了替代拼接 (AS) 监管格局. 他们确定了关键的RNA结合蛋白 (RBPs),驱动神经元身份和特定的拼接程序,揭示了基因表达之外的分子多样性.

关键词:
第122章 没有了RNA拼接规则的调节RNA结合蛋白质是RNA结合的蛋白质.网络推断 网络推断神经元亚型的神经元亚型

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相关概念视频

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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