通过Stat3介导的Atg7表达增强了黑色素瘤的抗瘤免疫力
Sarah M Zimmerman1,2, Erin Suh3, Sofia R Smith1,2
1Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
bioRxiv : the preprint server for biology
|June 25, 2024
概括
黑色素瘤的进展涉及表观遗传变化和自. 删除自调节剂Atg7,减缓瘤生长,通过增加CD8+T细胞来增强抗瘤免疫力.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 表观遗传修饰,包括EZH2介导的H3K27me3,对于黑色素瘤的发展至关重要.
- 突变EZH2 (Y641F) 与Stat3相互作用,影响抗瘤免疫力.
- 黑色素瘤中EZH2的下游途径仍然不完全理解.
研究的目的:
- 在EZH2 Y641F突变的背景下,调查自调节器Atg7在黑色素瘤生长和免疫力中的作用.
- 探索Atg7,Stat3和黑色素瘤进展之间的关系.
- 确定Atg7删除对瘤免疫微环境的影响.
主要方法:
- 利用基因工程的黑色素瘤小鼠模型.
- 分析了自的特征和像Atg7.7这样的自调节者的表达.
- 在体外和体内评估了Atg7缺失对黑色素瘤细胞生长的影响.
- 在瘤微环境中评估免疫细胞群的变化.
主要成果:
- Atg7的表达显著依赖于Stat3的表达.
- 在体内,ATG7的缺失抑制了黑色素瘤细胞的生长,但在体内却没有.
- 删除Atg7导致瘤内的CD8+T细胞增加.
- 删除Atg7导致免疫抑制细胞的透减少.
结论:
- 在黑色素瘤的进展中,Atg7起着重要作用,部分由Stat3调解.
- 调节Atg7可以增强黑色素瘤的抗瘤免疫力.
- 在黑色素瘤中,表观遗传变化,自和免疫系统之间的相互作用至关重要.
相关概念视频
Tumor Immunotherapy
511
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
511
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K


