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Updated: Jun 23, 2025

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甲素B会导致托戈细胞结合中介的CAR-T细胞功能障碍

Kenneth A Dietze1, Kiet Nguyen2, Aashli Pathni3

  • 1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.

bioRxiv : the preprint server for biology
|June 25, 2024
PubMed
概括

化学抗原受体 (CAR) T细胞疗法面临由于CAR介导的细胞分裂 (CMT) 的复发. 抑制甲素B (CTSB) 防止CMT诱导的CAR T细胞耗尽和兄弟杀伤,改善CAR T细胞的持久性.

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