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Updated: Jun 23, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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中枢杏仁体天体细胞可塑性是乙醇依赖中GABAergic调节失调的基础

Todd B Nentwig1, J Daniel Obray1, Anna Kruyer1,2

  • 1Department of Neuroscience, Medical University of South Carolina, Charleston SC 29425, United States.

bioRxiv : the preprint server for biology
|June 25, 2024
PubMed
概括

酒精依赖导致杏仁体 (CeA) 中央核中的大脑变化,包括星球细胞可塑性和改变的GABA传播. 然而,天体细胞GAT3对于酒精饮用行为在依赖中并不重要.

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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