相关实验视频

Updated: Jun 23, 2025

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

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脊椎海马中的Prosapip1调解突触蛋白组成,长期增强和空间记忆

Zachary W Hoisington, Himanshu Gangal, Khanhky Phamluong

    bioRxiv : the preprint server for biology
    |June 25, 2024
    PubMed
    概括

    普罗萨皮1蛋白对于学习和记忆至关重要,它通过确保海马体中正确的突触蛋白定位来确保学习和记忆,从而支持长期潜能 (LTP). 它的缺失会损害记忆功能.

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    Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

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    Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents11:29

    Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

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    相关概念视频

    Long-term Potentiation01:25

    Long-term Potentiation

    Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
    Hebbian LTP
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    Long-term Depression01:03

    Long-term Depression

    Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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    Role of Hippocampus in Memory01:19

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    The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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    Postsynaptic Potential (PSP)01:32

    Postsynaptic Potential (PSP)

    Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
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