一个感觉运动关联轴的thalamocortical连接发展发展轴
Valerie J Sydnor1,2,3, Joëlle Bagautdinova1,2, Bart Larsen1,2,4
1Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
丘脑协调人类大脑的发育,其与皮质的连接沿着感觉运动到关联梯度成熟. 这有助于调节关联性大脑区域的发育时间和环境敏感性.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 人类大脑发育 人类大脑发育
背景情况:
- 人类皮层发育在整个儿童和青少年时期从感觉运动到关联区域进行.
- 调节皮层成熟时间的精确机制及其区域差异仍然不太清楚.
- 动物模型中的thalamic轴突信号影响皮质可塑性的关键时期.
研究的目的:
- 测试该假设的thalamocortical连接协调在青春期皮质区域的异步成熟.
- 开发和验证一个关于人类甲状腺皮层连接的新型地图.
主要方法:
- 创建和解剖学验证了使用扩散通道图的人类甲状腺皮层连接图谱.
- 将地图集应用于三个独立的青年数据集 (8-23岁;N=2,676).
- 分析了与皮层功能组织相关的甲状腺皮层连接的成熟轨迹.
主要成果:
- 甲状腺皮层连接表现出可重现的成熟梯度,反映了感觉运动与关联皮层轴.
- 皮层区域具有晚期成熟的胸膜连接,显示了长时间的可塑性和环境敏感性标记.
- 这种梯度与人类皮层成熟的既定序列保持一致.
结论:
- 丘陵体在编排皮层发育时间方面发挥着至关重要的作用.
- 甲状腺皮层的结构连接有助于协调人类皮层的成熟异时性.
- 这种协调会影响关联性大脑区域的环境敏感时期的发育可塑性.
更多相关视频
09:52Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
16:23Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
Published on: May 23, 2017
相关概念视频
Motor and Sensory Areas of the Cortex
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Somatosensory, Motor, and Association Cortex
Diencephalon: Thalamus and Information Relay
Overview of Somatic Sensory Pathways
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Major Somatic Sensory Pathways
