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Updated: Jun 23, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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TMEM106B C端片段聚合并驱动神经退行性蛋白质病变

Ruben Riordan1,2, Aleen Saxton1, Pamela J McMillan1,3

  • 1Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

bioRxiv : the preprint server for biology
|June 25, 2024
PubMed
概括

跨膜蛋白106B (TMEM106B) 在C. elegans模型中,C端片段聚合导致神经退行. 这种聚合驱动神经元功能障碍和损失,独立于益格拉努林水平,为蛋白质病变提供了洞察力.

关键词:
前側葉退化 前側葉退化在TDP-43中使用.在TMEM106B中使用.老化的老化 衰老的老化痴呆症 痴呆症是一种痴呆症.神经退行症的神经退行症益格拉努林是一种前列腺素.蛋白质病变是一种蛋白质病变.知道的 知道的 知道的

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