聚合微粒纳米颗粒能够在固体瘤中以图像为导向的药物输送
bioRxiv : the preprint server for biology
|June 25, 2024
概括
这项研究开发了新型纳米粒子,用于输送癌症药物chemocoxib A (CA) 并可视化瘤中的COX-2. 纳米技术可以实现向药物输送和实时成像固体癌症.
科学领域:
- 纳米技术和材料科学 材料科学
- 癌症生物学和治疗方法
- 生物医学成像技术 生物医学成像技术
背景情况:
- 固体瘤表现出高反应性氧物种 (ROS) 和表达循环氧化酶-2 (COX-2).
- 有针对性的药物输送和实时监测对于有效的癌症治疗至关重要.
- 开发响应的纳米载体,同时进行药物输送和成像,仍然是一个挑战.
研究的目的:
- 开发一种纳米技术,用于联合输送chemocoxib A (CA) 和一个COX-2向的,ROS可激活的亲光探针 (fluorocoxib Q,FQ).
- 为了实现实时可视化药物输送和固体瘤中的COX-2表达.
- 评估ROS敏感药物释放和瘤向in vitro和in vivo的疗效.
主要方法:
- 合成FQ和CA,然后共同封装成二块PPS135-b-POEGA17共聚合物纳米粒子 (FQ-CA-NP).
- 关于FQ-CA-NP的大小,泽塔潜力和ROS依赖的货物释放的特征.
- 在体外评估FQ-CA-NP吸收和货物释放在4T1癌细胞和原发性人类乳腺上皮细胞 (HMECs) 中.
- 在体内评估使用光成像和LC-MS/MS分析将FQ-CA-NP传递给小鼠的正位乳腺瘤.
主要成果:
- FQ-CA-NP的水力动力直径为109.2 ± 4.1 nm,而泽塔电位为-1.59 ± 0.3 mV.
- 在4T1细胞中观察到ROS依赖的货物释放,导致乳腺癌细胞生长的减少,而不会影响HMECs.
- 在体内成像证实了乳腺瘤中的NP积累,LC-MS/MS检测到瘤组织中的CA和FQ.
- 在健康的器官中没有检测到任何显著的NP衍生光.
结论:
- 将FQ和CA联合封装成PPS135-b-POEGA17纳米颗粒,为ROS敏感药物释放提供了一个可行的策略.
- 该FQ-CA-NP使得有针对性的交付和COX-2-介导的可视化固体瘤,指导癌症治疗.
- 这种纳米技术有望提高癌症治疗的疗效和监测.
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