从婴儿期到青春期的上升听觉通路微观结构成熟的空间组织,使用一种新的纤维追踪方法
Kirsten M Lynch1, Stefanie C Bodison2, Ryan P Cabeen1
1Laboratory of Neuro Imaging (LONI), USC Mark and Mary Stevens Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA.
bioRxiv : the preprint server for biology
|June 25, 2024
概括
人类听觉通路的发展显示出区域差异,大脑干区域成熟之前的thalamocortical连接和右半球之前的左半球. 这项研究绘制了从婴儿期到青春期白质成熟的地图.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 神经成像是一种神经成像.
背景情况:
- 听觉感知依赖于中央听觉通路的经验依赖的发展.
- 人类听觉通路从婴儿期到青春期的结构性发展仍然不太了解.
研究的目的:
- 描述人类上升听觉通路的区域发展轨迹.
- 使用先进的神经成像绘制微观结构成熟时间和模式.
主要方法:
- 利用基于MRI的扩散通道图和沿通道分析.
- 使用扩散张力成像 (DTI) 和神经元导向分散和密度成像 (NODDI) 进行微观结构量化.
- 分析了从脑干到听力皮层的白质成熟,从婴儿到青春期的人类受试者.
主要成果:
- 在整个听觉途径中确定了白质成熟的空间变化模式.
- 在较低的脑干区域观察到较早的成熟,与thalamocortical投影相比.
- 发现左半球与右半球相对较早的发展.
结论:
- 描述了人类听觉通路微观结构成熟的发展时间表和区域差异.
- 提供了对功能性听觉处理开发背后的过程的见解.
- 建立了识别非典型听觉通路发展的基线.
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