SGLT2抑制剂在成年移植受体中纠正液体过载-一项前性观察性研究
Anja Schork1,2,3, Marie-Luise Eberbach1,2,3, Ferruh Artunc1,2,3,4
1Department of Internal Medicine IV, Division of Diabetology, Endocrinology, Nephrology, University Hospital Tübingen, Tübingen, Germany.
概括
-葡萄糖共运输体2抑制剂 (SGLT2I) 通过减少过度水分而不会导致脱水,在移植接受者 (KTRs) 中安全地管理液体过载. SGLT2I对葡萄糖和体重的影响是由功能调节的.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 移植医学 移植医学
背景情况:
- 移植接受者 (KTRs) 经常经历液体过载.
- -葡萄糖共运输体2抑制剂 (SGLT2I) 越来越多地用于管理糖尿病和心力衰竭等疾病.
- 在KTR中SGLT2I的安全性和有效性需要进一步调查,特别是关于体积状态和功能.
研究的目的:
- 评估SGLT2I对移植受体体内构成,体积状况和功能的影响.
- 评估SGLT2I对激素标记物的影响,如血内和阿尔多斯特.
- 确定SGLT2I治疗KTR患者的安全性和有效性,重点关注液体平衡和功能维护.
主要方法:
- 长度观察性研究涉及22名移植接受者 (KTRs).
- 测量包括尿液中的葡萄糖,身体成分,体积状态 (生物阻抗光谱),血雷宁和阿尔多斯特.
- 在基线,一周和SGLT2I治疗开始后的1,3,6个月收集的数据.
主要成果:
- SGLT2I治疗导致基线过水的患者的液体过载减少,而不会导致脱水.
- 估计的淋巴细胞过率 (eGFR) 显示在1周后短暂下降,然后稳定.
- 尿中的葡萄糖度与eGFR相关,以及SGLT2I对HbA1c,禁食血糖和体重的影响在KTRs中减弱.
- 血的阿尔多素增加,而血胆素保持不变.
结论:
- 在移植患者中,SGLT2I疗法可以有效地纠正移植患者的液体过载,其基线过水率较高.
- 该疗法对KTRs似乎是安全的,在evolemic个体中保持稳定的液体状态并避免脱水.
- 在KTR中,SGLT2I对血糖控制和体重的影响受其估计的淋巴球过率 (eGFR) 的影响.
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