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相关概念视频

Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Updated: Jun 23, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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KEAP1-NRF2系统调节与年龄相关的精子生成功能障碍.

Sohei Kuribayashi1, Shinichiro Fukuhara1, Hiroaki Kitakaze1

  • 1Department of Urology Osaka University Graduate School of Medicine Suita Japan.

Reproductive medicine and biology
|June 25, 2024
PubMed
概括

老龄化增加了男性不孕症的风险. 这项研究将KEAP1-NRF2氧化应激系统与与年龄相关的精子生产和功能下降联系起来,提供潜在的治疗点.

关键词:
KEAP1NRF2 的时间.老化的老化 衰老的老化男人的不孕不育症.氧化应激是一种氧化应激.

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科学领域:

  • 生殖生物学 生殖生物学
  • 老龄化的分子机制.
  • 氧化应激研究研究 氧化应激研究

背景情况:

  • 父亲年龄的增加是一个全球趋势.
  • 先进的父亲年龄与男性不孕症有关.
  • 精子生成中受老化影响的特定分子通路尚未完全理解.

研究的目的:

  • 调查KEAP1-NRF2氧化应激通路在精子生成与年龄相关的变化中的作用.
  • 探索衰老,氧化应激和男性生育能力之间的关系.

主要方法:

  • 对不同年龄的小鼠 (10-90周) 的精子数量,运动性和蛋白质表达的比较分析.
  • 在老年小鼠中使用巴多克索隆甲基对KEAP1抑制的评估.
  • 在患有非阻塞性阿佐精子症的人群中进行全外组测序.

主要成果:

  • 在老鼠中,随着年龄的增长,精子数量显著下降.
  • 在老化丸中观察到高氧化应激和KEAP1表达.
  • 在老年小鼠中KEAP1抑制改善了精子计数.
  • 一种特定的NRF2相关的SNP在不孕男性中更为频繁.

结论:

  • KEAP1-NRF2系统在与年龄相关的精子生成功能障碍中起着至关重要的作用.
  • 准KEAP1-NRF2通路可能为与衰老相关的男性不孕症提供治疗策略.