患有突破性COVID-19感染的青少年需要住院治疗:一项多中心回顾性研究
Zümrüt Şahbudak Bal1, Sema Yildirim Arslan1, Gizem Guner Ozenen2
1Department of Pediatric Infectious Diseases, Ege University Faculty of Medicine, İzmir, TUR.
Cureus
|June 25, 2024
概括
土耳其青少年的COVID-19疫苗接种计划显著减少了COVID-19和儿童多系统炎症综合征 (MIS-C) 的住院病例. 突破性感染通常是轻微的,在接种疫苗后三个月内发生.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 广泛的COVID-19疫苗接种导致病例大幅下降.
- 土耳其的青少年 (≥12岁) 被纳入2021年8月开始的全国性疫苗接种计划.
- 这项研究评估了该计划对青少年因COVID-19和MIS-C住院治疗的影响.
研究的目的:
- 确定COVID-19青少年疫苗接种计划对住院治疗的影响.
- 为了在接种疫苗前和接种疫苗期间比较COVID-19和MIS-C住院情况.
- 将突破性COVID-19感染的临床特征和严重程度与未接种疫苗的青少年进行比较.
主要方法:
- 追溯多中心研究,比较两个12个月期间的住院数据:前接种疫苗 (PVP) 和接种疫苗 (VP).
- 对0-18岁儿童的COVID-19和MIS-C住院病例的分析.
- 在VP期间,医院住院的青少年突破性感染 (12-18岁) 的特征,危险因素和结果与未接种疫苗的同龄人进行比较.
主要成果:
- 青少年住院 (12-18岁) 的比例从PVP的35.4%降至VP的18.6% (RR:0.6467,p < 0.001).
- 突破性COVID-19病例年龄较大,因COVID-19住院的频率较低 (OR:0.347),主要无症状/轻度 (OR:5.718).
- 较少的突破病例需要儿童重症监护室 (PICU) 的入院 (OR:0.188),大多数发生在最后一剂疫苗接种后的三个月内.
结论:
- 在土耳其,COVID-19疫苗接种计划显著减少了青少年因COVID-19和MIS-C住院的情况.
- 青少年的疫苗突破性感染通常不如未接种疫苗的个体严重.
- 研究结果支持青少年COVID-19疫苗接种的重要性,并可能影响疫苗犹.
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