非糖尿病成年人的胰岛素抵抗和白质微观结构异常:基于人口的研究
Mengyuan Zhou1,2, Yijun Zhou3, Jing Jing1,2
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
概括
胰岛素抵抗 (IR) 与非糖尿病成年人的白质异常有关. 然而,高血压和心血管疾病史显著影响了这一关联,这表明了潜在的干预目标.
科学领域:
- 神经成像是一种神经成像.
- 代谢健康 代谢健康
- 血管生物学 血管生物学
背景情况:
- 胰岛素抵抗 (IR) 是一个日益严重的健康问题,与白质完整性有着争论的联系.
- 了解这种关联对于识别风险人群和潜在干预措施至关重要.
研究的目的:
- 研究非糖尿病成年人胰岛素抵抗 (IR) 和白质完整性之间的关系.
- 探索高血压和心血管疾病等因素如何改变这种关联.
主要方法:
- 从PRECISE研究中对1709名非糖尿病成年人的横截面分析.
- 利用扩散权重成像 (DWI) 和基于通道的空间统计 (TBSS) 来评估白质微观结构.
- 使用胰岛素敏感性指数 (ISI复合,ISI0,120) 和HOMA-IR测量IR,并进行多变量回归分析.
主要成果:
- 胰岛素耐药性 (IR) 与多个白质区域的扩散性 (平均,轴向,辐射) 的增加有显著联系.
- 与ISI复合和ISI0,120测量胰岛素敏感性的关联更为明显.
- 在对高血压,心血管疾病史和药物使用进行调整后,IR对白质完整性的影响减少了.
结论:
- 胰岛素抵抗 (IR) 与非糖尿病中年成人白质微观结构异常有关.
- 高血压,心血管疾病史和相关药物在很大程度上影响了这些关联.
- 保持低IR可能是维护白质完整性的策略,需要进一步调查.
更多相关视频
08:22Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
Published on: March 20, 2017
8.7K
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
9.7K
相关概念视频
01:15Diabetes: Symptoms, Diagnosis, and Complications
522
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
522
01:30Attention-Deficit/Hyperactivity Disorder
55
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
55
01:22Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K