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在过渡期护理中对青少年异常性关节炎的疾病活动评估
F La Torre1, C Coppola2, M G Anelli3
1Department of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari. latorre_francesco@virgilio.it.
Reumatismo
|June 25, 2024
概括
在过渡期评估青少年异常性关节炎 (JIA) 疾病活动是具有挑战性的. 简化疾病活动指数 (SDAI) 和青少年关节炎疾病活动评分71 (JADAS71) 显示出强烈的相关性,有助于为JIA患者提供过渡性护理.
科学领域:
- 类风湿病学 类风湿病学
- 儿科风湿病学 儿科风湿病学
- 临床医学 临床医学
背景情况:
- 青春期异常性关节炎 (JIA) 需要在童年和成年期进行不同的疾病活动测量.
- 将JIA患者转移到成人护理的过程中,由于不同的指数,在准确评估疾病状况方面存在挑战.
- 标准化评估对于在关键护理阶段的有效管理至关重要.
研究的目的:
- 评估在接受过渡性护理的JIA患者中成人和青少年疾病活动得分之间的相关性.
- 确定最可靠的指数,用于测量从儿科到成人医疗机构的过渡期间的JIA疾病活动.
主要方法:
- 在JIA患者 (16岁以上) 转变期间使用青少年关节炎疾病活动评分71 (JADAS71),成人疾病活动评分 (DAS28),简化疾病活动指数 (SDAI) 和临床疾病活动指数 (CDAI) 评估疾病活动.
- 在基线和12个月过渡后评估疾病活性.
- 使用回归分析来量化不同评估指数之间的一致性.
主要成果:
- 分析了26名JIA患者,并使用多个指数评估疾病活性.
- 在JADAS71和成人指标之间观察到强烈的相关性:r2=0.69与DAS28,r2=0.86与SDAI,r2=0.81与CDAI.
- 简化疾病活动指数 (SDAI) 和JADAS71显示了最高的相关性.
结论:
- 在过渡期护理期间,SDAI和JADAS71在评估JIA患者的疾病活性方面表现出最强的一致性.
- 尽管存在很强的相关性,但在某些患者的疾病活性评估中发现了差异.
- 建议对更大的队列进行进一步的前性研究,以验证这些发现并完善评估工具.
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