神经肌肉阻断剂药物挑战:文献综述和议定书提案,包括生物评估
Aurélie Gouel-Chéron1, Catherine Neukirch, Sylvie Chollet-Martin
1From the Anaesthesiology and Critical Care Medicine Department, DMU PARABOL, Bichat Hospital, AP-HP (AG-C, DL, PM), Antibody in Therapy and Pathology, Pasteur Institute, UMR 1222 INSERM (AG-C, LdC), Paris Cité University (AG-C, BP, DL, PM, LdC), C2A: WAO Centre of Excellence for Allergy and Asthma (AG-C, CN, SC-M, DL, PN-R, LdC), Pulmonology Department, Bichat Hospital, AP-HP, Paris Cité University (CN), Université Paris Cité, Inserm, PHERE (CN), Immunology department, 'autoimmunity, hypersensitivities, and biologics', DMU BIOGEM, Bichat Hospital, AP-HP, Paris (SC-M, PN-R, LdC), Université Paris-Saclay, Inflammation, Microbiome and Immunosurveillance, INSERM, Orsay (SC-M, PN-R, LdC), Anaesthesiology, Critical Care and Burn Unit Department, DMU PARABOL, Saint-Louis Hospital, AP-HP, Paris (AV, BP) and INSERM UMR-S942, Lariboisière Hospital and INI-CRCT network, France (BP).
神经肌肉阻断剂 (NMBA) 药物挑战对于诊断NMBA过敏至关重要,当标准测试没有确定性时. 在专业中心实施这些挑战可以提高患者的安全性,并指导未来的麻醉.
科学领域:
- 麻醉学 麻醉学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 药物挑战是对过敏诊断的黄金标准,但对于神经肌肉阻断剂 (NMBA) 不是经常推的.
- 标准的过敏检查可能会忽略非IgE介导反应.
- NMBA的挑战是复杂的,需要专门的设置和专业知识.
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