将非目标分析与基于计算机的危险比较方法结合起来,以支持在生物固体中优先考虑不受管制的有机污染物
Matthew N Newmeyer1, Qinfan Lyu1, Jon R Sobus2
1Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Environmental science & technology
|June 25, 2024
概括
应用于农田的生物固体可能含有不受管制的有机污染物. 新的技术识别并优先考虑了关键污染物,如p-cresol和fludioxonil,用于未来的环境研究.
科学领域:
- 环境化学环境化学
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
背景情况:
- 废水副产品生物固体被用作农业肥料.
- 目前对陆地应用的生物固体的规定侧重于金属和病原体,而不是有机污染物.
- 需要新的分析技术来检测和评估与生物固体相关的有机污染物 (BOC).
研究的目的:
- 在美国和加拿大生物固体中识别和优先考虑BOC.
- 将非目标分析 (NTA) 与计算毒理学相结合,用于危险评估.
- 为未来关于优先考虑的BOCs环境命运和运输的研究提供信息.
主要方法:
- 利用非目标分析 (NTA) 在16个生物固体样本中检测出广泛的化学物质.
- 采用美国环保署的化学信息学危险比较模块 (HCM) 进行危险评估和优先排序.
- 对92个检测到的化合物确认或赋予了可能的结构.
主要成果:
- 在至少80%的生物固体样本中检测到451个特征.
- 标识的化合物主要是内源性化合物,药品,工业化学品和香料.
- 优先考虑人体健康的p-cresol和,以及生态健康的fludioxonil和triclocarban.
结论:
- 非目标分析与危险比较相结合,有效地识别和优先考虑BOC.
- 这种方法有助于评估与生物固态土地应用相关的潜在人类和生态风险.
- 已经确定了关键化合物,以进一步调查它们的环境行为.
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