甲基纳尔特雷克松对急性胰腺炎无影响 严重程度:多中心随机对照试验
Cecilie Siggaard Knoph1,2, Mathias Ellgaard Cook1,2, Srdan Novovic3,4
1Mech-Sense and Centre for Pancreatic Diseases, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.
The American journal of gastroenterology
|June 25, 2024
概括
在临床试验中,甲基纳尔特雷没有改善急性胰腺炎 (AP) 的严重程度. 这项研究发现,在管理AP症状或疾病进展方面,甲基纳列和安慰剂之间没有显著差异.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 用于急性胰腺炎 (AP) 严重疼痛的阿片类药物,可能通过胃肠道和免疫效应使病情恶化.
- 作为外围作用的μ-阿片类受体对抗剂,甲基纳特雷克松正在研究其对抗这些阿片类药物诱导作用的潜力,而不会影响缓解疼痛.
研究的目的:
- 评估甲基纳特雷克松在减轻急性胰腺炎的严重性方面的疗效.
- 评估甲基纳特雷克松对疼痛评分,阿片类药物消费,疾病严重程度和AP患者死亡率的影响.
主要方法:
- 一项双盲,随机,安慰剂对照试验与被诊断为AP和全身炎症反应综合征的成年患者进行.
- 患者除了接受标准护理外,还接受了连续静脉注射甲基或安慰剂5天.
- 主要终点是48小时的胰腺炎活动评分系统得分;次要结果包括疼痛,阿片类药物使用和死亡率.
主要成果:
- 这项研究随机分配了105名患者接受甲基纳尔特雷克松 (n=51) 或安慰剂 (n=54).
- 在48小时内,在甲基纳特雷克松和安慰剂组之间的胰腺炎活动评分系统得分中没有发现显著差异 (P=0.87).
- 与安慰剂相比,甲基利没有显著改变疼痛评分,阿片类药物使用,疾病严重程度或死亡率.
结论:
- 在减轻急性胰腺炎的严重程度方面,甲基纳特雷克松治疗没有显示出对安慰剂的优越性.
- 该研究得出结论,在测试条件下,甲基纳尔特雷克松在降低AP严重性方面无效.
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