与更年期相关的睡眠障碍
Pauline M Maki1, Nick Panay2, James A Simon3
1From the University of Illinois, Chicago, IL.
概括
与更年期相关的睡眠障碍,以唤醒和增加清醒时间为特征,显著影响女性的健康. 了解底层的神经生物学为有针对性的治疗提供了潜在的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生殖内分泌学 生殖内分泌学
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍是绝经期间女性普遍和严重的症状.
- 目前的疗法尚未特别批准用于与更年期相关的睡眠问题.
- 本综述探讨了更年期睡眠障碍的特征,病因和影响.
研究的目的:
- 为了描述更年期的睡眠障碍.
- 讨论病因学,包括最近神经元电路的进展.
- 检查当前和未来的治疗策略.
主要方法:
- 文献综述. 这是一个文献综述.
- 关于睡眠和更年期的专家讨论.
- 临床实践经验整合.
主要成果:
- 更年期睡眠障碍涉及频繁的夜间觉醒和睡眠开始后增加的清醒时间.
- 影响扩展到整体健康,人际关系,生产力和工作表现.
- 激素变化,血管运动和情绪症状有助于睡眠障碍.
结论:
- 对于更年期睡眠障碍的有效和安全治疗方法存在重大未满足的需求.
- 承认睡眠障碍与更年期之间的联系至关重要.
- 了解下丘脑中对雌激素敏感的神经元 (kisspeptin/neurokinin B/dynorphin) 的理解,通过整合生殖,温度调节和睡眠和清醒的途径,为向治疗提供了一条途径.
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