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在异质的黄金葡萄球菌 (Staphylococcus aureus) 中介性细菌病中,木素治疗失败的危险因素
Ji Hyun Yun1, Euijin Chang2, Seongman Bae2,3
1Division of Infectious Diseases, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea.
Microbiology spectrum
|June 25, 2024
概括
老年患者和严重的感染增加了异构的米素中间体黄球菌 (hVISA) 细菌症中米素治疗失败的风险. 固体器官移植和低范科米辛最小抑制度 (MIC) 预测治疗成功.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 不同类型的米素中间体黄金葡萄球菌 (hVISA) 感染正在增加,导致米素治疗失败.
- 有限的研究调查了hVISA治疗失败的风险因素.
研究的目的:
- 为了确定临床和微生物学风险因素,在hVISA bacteremia的患者中发现万科米辛治疗失败.
主要方法:
- 对102名患有hVISA细菌病的患者进行了回顾性研究,这些患者接受了超过7天的万科米辛治疗.
- 治疗失败和成功组之间的临床和微生物特征的比较.
- 多变量分析以确定独立的风险因素.
主要成果:
- 在78%的患者中,万科米辛治疗失败了.
- 失败的独立风险因素:晚年和细菌病的严重程度.
- 与成功相关:固体器官移植 (SOT) 和万科米辛最小抑制度 (MIC) ≤1.0 mg/L通过微稀释 (BMD).
结论:
- 晚年和感染严重程度是hVISA细菌血症中万科米辛治疗失败的关键预测因素.
- 使用BMD确定万科米辛MIC对于指导hVISA感染的治疗决策至关重要.
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