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Updated: Jun 23, 2025

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Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
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在疑似结核病患者中,GeneXpert Mycobacterium tuberculosis/Rifampicin 阴性结果的影响:一项研究研究
Deby Kusumaningrum1,2,3,4, Ni Made Mertaniasih2,3,4, Soedarsono Soedarsono3,4,5
1Doctoral Degree Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
International journal of mycobacteriology
|June 25, 2024
概括
在怀疑结核病的患者中,GeneXpert MTB/RIF结果的阴性不排除非结核菌肺病 (NTMLD). 进一步的真菌细菌检测对于准确诊断和治疗慢性肺部疾病至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- GeneXpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) 的测定方法被广泛用于结核病 (TB) 的诊断.
- 负的MTB/RIF结果可能导致延迟诊断非结核菌肺病 (NTMLD),通常被误诊为多药耐药结核病 (MDR-TB).
- 在全球范围内,NTM疾病的患病率正在增加,需要改进诊断策略.
研究的目的:
- 评估GeneXpert MTB/RIF结果在疑似慢性肺结核患者中出现的负面影响.
- 为了将GeneXpert MTB/RIF阴性结果与真菌菌培养结果进行比较.
- 为了确定GeneXpert MTB/RIF测定结果为负的患者中NTMLD的发病率.
主要方法:
- 一项实验性研究涉及100名疑似慢性肺结核患者的唾液样本,GeneXpert MTB/RIF结果为阴性.
- 用洛文斯坦-詹森介质培养样本,以检测结核菌菌 (MTB) 和非结核菌菌 (NTM).
- 与GeneXpert和培养结果相关的肺部异常和临床诊断的评估.
主要成果:
- 菌根菌培养在7%的样本中证实了MTB,在1%的样本中证实了NTM.
- 34%的患者在临床上被诊断出结核病,并接受了抗结核药物治疗,尽管GeneXpert的结果是负面的.
- 该研究在一小部分患者中发现了NTMLD,这些患者的GeneXpert MTB/RIF测定结果为负.
结论:
- 在临床上怀疑的慢性结核病例中,GeneXpert MTB/RIF的负结果需要进一步调查.
- 菌根菌培养和其他诊断测试对于识别病原体,包括NTM至关重要.
- 及时诊断NTMLD至关重要,以避免误诊并确保适当的治疗.
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