流感感染和急性心肌梗塞
Annemarijn R de Boer1, Annelies Riezebos-Brilman2, Denise van Hout1
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
NEJM evidence
|June 25, 2024
概括
流感感染显著增加了急性心肌梗塞的风险,特别是在没有先前心脏病史的人群中. 这一发现突显了流感对心血管的影响,强调了预防措施的必要性.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 急性呼吸道感染,包括流感,已知是急性心肌梗塞 (AMI) 的触发因素.
- 量化实验室确认的流感和AMI之间的关联至关重要,特别是考虑到先前存在的冠状动脉疾病 (CAD).
研究的目的:
- 为了确定实验室确认的流感感染和急性心肌梗塞的发生之间的关联.
- 在有或没有冠状动脉疾病病史的患者中调查这一关联.
主要方法:
- 采用了基于注册的观察性,自我控制的案例系列研究设计.
- 来自实验室确认的流感 (通过PCR) 和AMI诊断的国家登记处的数据被链接起来.
- 在风险期 (感染后1-7天) 中,AMI的发生率与对照期 (感染前1年和感染后51周) 相比较.
主要成果:
- 在2008年至2019年期间,共有23,405个流感病例被确定.
- 与对照期相比,在流感后的风险期内,AMI的调整后的相对发病率为6.16.
- 没有先前CAD住院治疗的个体与先前CAD住院治疗的个体相比,相对发病率显著更高 (16.60) (1.43).
结论:
- 实验室确认的流感感染与急性心肌梗塞的风险大幅增加有关.
- 这种风险在没有冠状动脉疾病住院病史的个人中特别高.
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