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Published on: March 31, 2023
[心脏粉症和大动脉狭窄:我们知道什么?]
Giuseppe Sena1, Irene Ruotolo1, Andrea Zaccaro1
1U.O. Cardiologia, IRCCS Azienda Ospedaliero-Universitaria di Bologna - Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (DIMES), Alma Mater Studiorum Università di Bologna - Membro del Network europeo per la gestione delle malattie miocardiche rare e/o complesse (ERN GUARD-Heart).
大动脉狭窄症和心脏粉样化症往往同时存在. 早期诊断和皮肤穿治疗改善了结果,心脏粉样化症不会对跨导管大动脉置换后的存活率产生负面影响.
科学领域:
- 心脏病学 心脏病学
- 心血管医学 心血管医学
- 氨基粉症研究研究
背景情况:
- 大动脉狭窄症 (AVS) 和心脏粉症 (CA),特别是与甲胺相关的,经常同时存在.
- 共享的临床和人口特征表明潜在的病理生理联系,尽管尚未完全阐明.
- 临床怀疑对于检测AVS患者的并发CA至关重要.
研究的目的:
- 突出承认AVS和CA的共存的重要性.
- 概述用于识别双重病理的诊断策略.
- 审查当前的治疗方法及其对患者结果的影响.
主要方法:
- 对诊断AVS同时发生的CA的临床,心电图,心声图和心外"红旗"的审查.
- 讨论确定诊断的非侵入性诊断步骤.
- 对现有治疗数据的分析,将皮肤间干预与医学治疗进行比较.
主要成果:
- 双重病理的早期诊断至关重要,因为它在没有干预的情况下会使预后恶化.
- 膜性心脏病的皮肤纠正显示出比单独使用药物治疗更好的存活率和更少的心血管事件.
- 尽管再入院病例增加,心脏粉症似乎并没有显著影响透气管术后大动脉置换 (TAVR) 后的生存率.
结论:
- 穿皮治疗膜心脏病是AVS和CA患者的主要治疗策略.
- 在等待进一步的数据之前,可能会考虑在TAVR后对转氨基粉症进行疾病修饰疗法,以延迟进展.
- 专注于及时干预的综合管理是改善这一复杂患者群体结果的关键.
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