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Updated: Jun 23, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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血管光滑肌细胞中的NRF2/ID2轴:关于血管化和衰老之间的相互作用的新见解

Mulin Xu1,2,3, Xiuxian Wei1,2, Jinli Wang1,2

  • 1Department of Geriatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Aging and disease
|June 25, 2024
PubMed
概括

衰老会损害血管光滑肌细胞中的核因素2 (NRF2),促进血管化 (VC). 在VSMC中激活NRF2-ID2通路可以预防与年龄相关的VC和心血管疾病.

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Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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