在初始治疗阿弗利塞普特后,在患有糖尿病黄斑的眼睛中切换为法里西马布
Francesco Pichi1,2, Abdulhamid Abdi3, Shaikha Aljneibi4
1Eye Institute, Cleveland Clinic Abu Dhabi, PO Box 112412, Al Maryah Island, Abu Dhabi, United Arab Emirates. ilmiticopicchio@gmail.com.
International ophthalmology
|June 25, 2024
概括
切换到法利西马布改善了视力和减少了视网膜的糖尿病黄斑 (DME) 患者先前用aflibercept治疗. 这表明法里西马布对抗药性DME病例有效.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理干预药理干预
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 抗血管内皮生长因子 (抗VEGF) 疗法,如阿弗利塞普特,是DME的标准治疗方法.
- 一些患者对现有治疗没有充分的反应,需要替代治疗策略.
研究的目的:
- 在患有DME的患者中,评估从aflibercept转换为faricimab的疗效.
- 在切换后评估视觉敏度和视网膜厚度的变化.
主要方法:
- 这是一项追溯性,单一中心的研究,对100名以前用aflibercept治疗的DME患者进行了研究.
- 患者在平均6.8次aflibercept注射后被转换为法里西马布.
- 最好的校正视敏度 (BCVA) 和中央子场厚度 (CST) 在基线,切换和6个月后续测量.
主要成果:
- 被归类为对aflibercept"视觉反应不佳"的患者在转换后6个月显示出显著的BCVA改善 (+5个字母) 和CST减少 (-67.9微米) (分别P=0.007和P=0.004).
- 对阿弗利塞普特"解剖反应不佳"的患者也表现出功能增长 (+4.5个字母;P=0.05) 与一些CST减少 (-95.1微米;P=0.05).
- 法里西马布在对aflibercept耐药的DME患者中显示出积极的解剖和功能效应.
结论:
- 法里西马布为那些对aflibercept不耐药的DME患者提供了一种有益的治疗选择.
- 转换为法里西马布可以导致视觉功能和视网膜的显著改善.
- 这项研究强调了法里西马布在管理具有挑战性的DME病例方面的潜力.
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