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Updated: Jun 23, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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开发一种强效和选择性的G2A (GPR132) 激进剂

Victor Hernandez-Olmos1,2, Jan Heering1,2, Beatrice Marinescu3

  • 1Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.

Journal of medicinal chemistry
|June 25, 2024
PubMed
概括

研究人员发现了一种新的G2A激动剂T-10418,它是研究G蛋白结合受体G2A的强大和有选择性的工具. 这种化合物显示出开发针对神经病痛,白血病和炎症的治疗方法的希望.

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Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

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