与登革热并发症和死亡相关的危险因素:秘鲁的一个队列研究
Cesar Copaja-Corzo1,2, Javier Flores-Cohaila3, Gustavo Tapia-Sequeiros4
1Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Perú.
PloS one
|June 25, 2024
概括
秘鲁的登革热死亡与升高的胆红素水平有关. 伴随性疾病和先前的登革热感染表明预后不佳,突出表明在流行地区需要更好的诊断.
科学领域:
- 热带医学 热带医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 登革热在秘鲁是一个日益严重的流行病挑战,气候变化加剧了这种挑战.
- 这项研究调查了秘鲁普卡尔帕登革热死亡率的风险因素.
研究的目的:
- 为了确定与登革热相关死亡相关的风险因素.
- 确定预测严重登革热或重症监护室 (ICU) 入院的因素.
主要方法:
- 152名登革热患者的回顾性队列研究 (2019年1月至2023年3月).
- 考克斯回归模型分析了死亡率和严重结果的风险因素.
- 关键指标包括胆红素水平,并发症,AST,先前登革热病史和纤维素原体.
主要成果:
- 13名 (8.6%) 患者死亡;29名 (19.1%) 患有严重的登革热;31名 (20.4%) 患者需要接受ICU治疗.
- 升高的 bilirubin (>1.2 mg/dL) 显著增加了死亡风险 (aHR: 11.38).
- 伴随性疾病,高AST,先前登革热感染和纤维素素水平升高与预后不佳有关.
结论:
- 升高的胆红素是登革热死亡率的关键指标.
- 伴随性疾病和以前的登革热感染预测疾病结果较差.
- 加强实验室准入对于在热带高发病率地区早期检测严重登革热至关重要.
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