在患有轻度自主皮质醇分泌的患者中,认知功能和由大脑衍生的神经营养因子
Tugba Barlas1, Muhammed Hakan Aksu2, Ethem Turgay Cerit1
1Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey.
European journal of endocrinology
|June 25, 2024
概括
轻度自主皮质醇分泌 (MACS) 与较高的大脑衍生神经营养因子 (BDNF) 水平有关,可能会保护记忆. 与对照组相比,MACS患者的认知功能,特别是记忆和语言受到了影响.
科学领域:
- 神经内分泌学神经内分泌学
- 认知神经科学 认知神经科学
- 内分泌学 在内分泌学.
背景情况:
- 在轻度自主皮质醇分泌 (MACS) 中,皮质醇分泌异常与认知缺陷之间的关系尚不清楚.
- 皮质醇失调与各种神经和精神疾病有关.
研究的目的:
- 评估MACS患者的认知功能.
- 在MACS患者中测量血清脑衍生神经营养因子 (BDNF) 水平.
- 探索认知领域与BDNF度之间的相关性.
主要方法:
- 一项前性研究涉及84名参与者:28名MACS患者,28名非功能性上腺腺瘤 (NFAA) 患者和28名匹配对照.
- 使用蒙特利尔认知评估 (MoCA) 和精神病学面试进行认知评估.
- 测量了血清BDNF度和皮质醇度 (德甲抑制试验).
主要成果:
- 马克斯患者的血清BDNF比NFAA患者高,而NFAA患者的BDNF比对照人群低.
- 在MACS和NFAA组之间的总体MoCA分数没有显著差异,但两者都低于对照组.
- 与NFAA相比,MACS患者表现出更好的记忆力,但语言得分较差.
- BDNF与记忆有积极的相关性,而甲抑制试验 (DST) 皮质醇与语言有负相关性.
结论:
- 在MACS中低度的高皮质醇症与BDNF升高有关.
- 升高的BDNF可以作为MACS患者记忆功能的补偿机制.
- 皮质醇水平影响特定的认知领域,表明复杂的相互作用.
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