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Updated: Jun 23, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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在Ph1+急性淋巴细胞白血病中,波纳替尼的脑脊液分布和药理动力学

Pierre Walczak1, Sofiane Fodil1,2, Nicolas Vignal3

  • 1Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Blood
|June 25, 2024
PubMed
概括

氨酸激酶抑制剂对中枢神经系统 (CNS) 疾病的疗效尚不清楚. 波纳替尼在费城阳性急性淋巴细胞白血病患者中显示出低于最佳的中枢神经系统暴露,因为脑脊液度低于有效值.

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