可解释的机器学习模型用于预测骨转移患者接受息性放射治疗的患者的整体存活率
Savino Cilla1, Romina Rossi2, Ragnhild Habberstad3,4
1Medical Physics Unit, Responsible Research Hospital, Campobasso, Italy.
JCO clinical cancer informatics
|June 25, 2024
概括
机器学习模型预测接受息性放射治疗的晚期癌症患者的1年生存率. 可解释的人工智能 (SHAP) 识别了关键因素,如互白素-8,血红蛋白和淋巴细胞计数,以便更好地分层患者和治疗决策.
科学领域:
- 在瘤学瘤学.
- 人工智能的人工智能
- 生物统计学 生物统计学
背景情况:
- 预后和预期寿命估计对于晚期癌症患者的护理至关重要.
- 骨转移的息性放射治疗 (RT) 旨在改善生活质量.
- 准确的生存预测有助于临床决策.
研究的目的:
- 使用机器学习 (ML) 和可解释AI (XAI) 开发预测策略.
- 为了预测骨转移的息性RT后的一年生存率.
- 为了提高晚期癌症患者的临床决策.
主要方法:
- 利用了多中心PRAIS试验 (574名符合条件的成年人) 的数据.
- 使用Python开发和验证ML模型,评估歧视.
- 执行了全球和本地特征重要性的沙普利增量解释 (SHAP).
主要成果:
- 极端梯度增强模型实现AUC0.805和F1得分0.802为1年生存预测.
- 在SHAP分析中,低interleukin-8,高血红蛋白,高淋巴细胞数量和不使用类固醇与更高的一年生存率相关.
- 确定了关键的临床,实验室和治疗变量.
结论:
- 可解释的ML提供了可靠的1年生存预测后RT在晚期癌症.
- SHAP分析提供了可理解的个性化风险解释.
- 这种方法有助于瘤学家在患者分层和治疗选择.
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