间歇性禁食对肝功能测试的影响:随机临床试验的系统审查和元分析
Mahsa Ranjbar1, Sakineh Shab-Bidar2,3, Hamed Mohammadi1
1Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, 14155-6117, Iran.
间歇性禁食 (IF) 通过降低ALT,AST和GGT等肝脏关键酶,有望改善肝脏健康. 这一系统性审查表明,IF可能有利于整体肝功能,尽管对ALP的影响并不显著.
科学领域:
- 代谢健康和营养科学 代谢健康和营养科学
- 胃肠病学和肝病学
背景情况:
- 间歇性禁食 (IF) 是一种饮食模式,涉及循环饮食和自愿禁食.
- 虽然IF已知有减肥和心脏代谢益处,但其对肝功能测试 (LFT) 的影响需要澄清.
研究的目的:
- 系统地审查和元分析随机临床试验 (RCT),评估间歇性禁食对肝功能测试的影响.
主要方法:
- 在PubMed,Scopus和ISI Web of Science进行了全面的文献搜索,直到2023年2月.
- 包括14个具有908名参与者的RCT,遵守PRISMA指南.
- 评估了偏差风险,并使用加权平均差异 (WMDs) 分析了结果,使用95%的置信区间 (CI).
主要成果:
- 间歇性禁食显著降低了氨酸转移酶 (ALT) 和酸氨酸转移酶 (AST) 的水平.
- 观察到马-谷氨基胺转化酶 (GGT) 水平显著降低,特别是在非酒精性脂肪肝疾病和ALT健康组中.
- 在性酸酶 (ALP) 水平中没有发现显著变化,在研究中异质性很低.
结论:
- 间歇性禁食通过改善ALT,AST和GT水平,对肝功能产生有益影响.
- IF似乎没有显著改变ALP水平.
- 这些发现表明,IF可能是改善肝脏健康的可行策略.
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