动脉构成模型在从脉冲波速度预测血压方面的关键作用
Aditya Satishkumar Bantwal1, Amit Kumar Bhayadia1, Hui Meng1
1Department of Mechanical and Aerospace Engineering, University at Buffalo, Buffalo, NY, 14260, USA.
Computers in biology and medicine
|June 25, 2024
概括
从脉冲波速度 (PWV) 估计血压 (BP) 需要考虑动脉壁.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
- 计算力学 计算力学 计算力学
背景情况:
- 持续监测血压对于心血管健康管理至关重要.
- 从脉冲波速度 (PWV) 估计血压 (BP) 的现有无袖方法通常依赖于简化的动脉模型,导致显著的预测错误.
- 这些错误可能源于对细壁,带有小变形的线性弹性动脉的假设.
研究的目的:
- 在没有简化动脉模型的约束的情况下,研究血压 (BP) 和脉冲波速度 (PWV) 之间的关系.
- 了解动脉壁机制如何影响BP-PWV关系.
主要方法:
- 液体结构相互作用 (FSI) 模拟在生理流动下在放射性和常见的动脉上进行.
- 使用了两种动脉壁构成模型:线性弹性模型和Holzapfel-Gasser-Ogden (HGO) 模型,该模型考虑了非线性效应.
- HGO模型结合了原纤维机制和大动脉变形.
主要成果:
- 线性弹性模型不准确地预测了恒定的PWV,无法反映生理变化.
- HGO模型准确地捕捉了非线性动脉变形,预测了正面的BP-PWV相关性.
- 在HGO模型中,PWV在心脏周期内变化高达50%.
结论:
- BP-PWV关系高度依赖于动脉构成模型,特别是辐射动脉.
- 从PWV精确估计血压需要考虑时间变化的PWV,由非线性动脉反应驱动.
- 未来的研究应该专注于精确测量时间变化的PWV,以便可靠地预测BP.
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