洞察自然混合维度阿塔普尔吉特粘土的静血性能和机制
Xiaomei Wang1, Yinfeng Yang2, Fangfang Yang1
1Key Laboratory of Clay Minerals of Gansu Province, Research Center of Resource Chemistry and Energy Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
Biomaterials advances
|June 25, 2024
概括
自然的混合维度阿塔普尔吉特粘土 (MDAPT) 显示出出色的静血特性. 这项研究使用酸优化了MDAPT,证明了其作为一种有效的无机血静性材料的潜力,用于宝贵的天然粘土资源.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 地质地质地质地质地质地
背景情况:
- 粘土矿物质以其生物相容性和独特的结构而闻名,使其成为生物医学应用的前景.
- 对自然混合粘土沉积物的研究,特别是用于静血应用,仍然有限.
研究的目的:
- 为了研究自然混合维度阿塔普尔吉特粘土 (MDAPT) 的静血性能.
- 为了探索MDAPT的结构演变,使用氧酸治疗增强血静.
- 评估MDAPT作为一种高效的无机血静性材料的潜力.
主要方法:
- 通过使用酸进行结构修饰,对MDAPT的静血性能进行系统的研究.
- 在体外评估凝固时间,血红蛋白吸收率和血液凝固指数.
- 在体内评估出血时间和减少血液损失.
- 对影响血液静止的结构和表面特性进行分析.
主要成果:
- 用酸治疗1小时的MDAPT显著减少了凝血时间 (134±12.17秒),并改善了血液凝血指数 (+19.45%).
- 在体内研究显示出最短的出血时间 (158.5±6.9秒) 和大量减少失血 (高达66%).
- 增强的血液静止归因于伊利特和阿塔普尔吉特的协同作用,超性,负面电荷和血小板激活的增加 (+21%).
结论:
- 优化的MDAPT显示出强大的静血能力,在体外和体外试验中表现优于对照试验.
- 这些发现突出了混合维度的粘土成分和表面特性对快速血液静止的协同贡献.
- 这项研究为高价值利用天然混合粘土资源作为有效的无机血静剂提供了可行的策略.
更多相关视频
相关概念视频
Clot Retraction and Fibrinolysis
5.4K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.4K
Formation of the Platelet Plug
5.8K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
5.8K
Extrinsic and Intrinsic Pathways of Hemostasis
7.1K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
7.1K
Introduction to Hemostasis
7.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
7.2K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
675
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
675
Coagulation
6.1K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
6.1K


