在医院治疗的传染病,遗传易感性和2型糖尿病的风险:基于人口的纵向研究
Jiazhen Zheng1, Quan Yang2, Jinghan Huang3
1Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong, China.
Diabetes & metabolic syndrome
|June 25, 2024
概括
感染增加了2型糖尿病 (T2D) 的风险,特别是严重的细菌感染,如败血症. 这种风险是累积的,受遗传倾向的影响,突出显示了感染对T2D发展的长期影响.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 感染和2型糖尿病 (T2D) 风险之间的联系尚未得到充分证实.
- 了解这种关联对于公共卫生战略至关重要.
研究的目的:
- 调查各种传染病之间的纵向关联以及随后发展T2D的风险.
- 探索影响这种关联的因素,包括感染类型,部位,严重程度和遗传倾向.
主要方法:
- 这是一项前性队列研究,对来自英国生物库的396080名参与者进行了前性队列研究,在基线没有糖尿病.
- 感染和T2D发病率使用ICD-10代码进行识别.
- 随时间变化的考克斯比例危险模型评估了这种关联,考虑了感染负担和T2D遗传风险评分 (GRS).
主要成果:
- 在医院治疗的感染与54%的T2D风险增加有关 (aHR为1.54).
- 细菌感染,特别是败血症 (aHR 2.95) 和血液感染 (aHR 3.01) 的风险最高.
- 观察到感染负担和T2D风险之间的剂量反应关系,由高遗传风险放大.
结论:
- 传染病与随后的T2D风险显著增加有关.
- 风险因感染特征而异,并且可能是累积的.
- 遗传因素和感染负担相互作用,调节T2D风险.
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