血红蛋白度与阻塞性睡眠呼吸暂停综合征之间的关系:系统性审查和元分析
Stefano Zoroddu1, Biagio Di Lorenzo1, Salvatore Sotgia1
1Department of Biomedical Sciences, University of Sassari, 07100, Sassari, Italy.
Sleep medicine
|June 25, 2024
概括
较高的血红蛋白 (Hb) 水平与阻塞性睡眠呼吸暂停综合征 (OSAS) 有关. 严重的OSAS病例显示Hb度的升高甚至更大,这表明存在潜在的生物标志物联系.
科学领域:
- 肺和睡眠医学 肺和睡眠医学
- 血液学 血液学 血液学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 是一种普遍存在的疾病,对健康有重大影响.
- 血红蛋白 (Hb) 度与OSAS有事相关,但缺乏全面的综合证据.
研究的目的:
- 系统地审查和对有关血红蛋白度与阻塞性睡眠呼吸暂停综合征之间的关联的现有文献进行元分析.
- 考虑到疾病严重程度,量化Hb水平和OSAS之间的关系.
主要方法:
- 在PubMed,EMBASE和Cochrane图书馆进行了系统的文献搜索,直到2024年3月8日,遵守PRISMA指南.
- 包括的研究包括横截面,队列和病例对照设计,比较OSAS患者和对照者的Hb.
- 数据提取和偏差风险评估由两位审查员独立地使用Joanna Briggs Institute检查清单进行.
主要成果:
- 在分析中包括了27项研究,其中包括6499名OSAS受试者和5199名对照者.
- 与对照组相比,在OSAS患者中观察到Hb度的统计显著升高 (SMD:0.28;95%CI:0.18至0.39).
- 亚组分析显示,与轻度/中度OSAS患者相比,重度OSAS患者的Hb水平较高;灵敏度分析支持了这些发现.
结论:
- 在阻塞性睡眠呼吸暂停综合征患者中,血红蛋白度明显升高,特别是在严重的情况下.
- 研究之间显著的异质性和地理集中 (主要是土耳其) 需要在不同人群中进行进一步的研究.
- 潜在的出版偏见和研究方法的变化代表了需要考虑的局限性.
相关概念视频
Sleep Apnea
143
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
143
Oxygen Transport in the Blood
2.6K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.6K
Factors Affecting Respiration
5.0K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
5.0K
Hypoxia
1.0K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.0K
Hemoglobin
3.5K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
3.5K
Acute Respiratory Failure-II
206
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
206


