对子宫内膜异位症的评估中的正子发射断层扫描:一个系统的审查
Rachael Fox1, Sarah Chang2, Lauren Hicks1
1The Royal Women's Hospital, 20 Flemington Rd, Parkville 3052, Victoria, Australia; Julia Argyrou Endometriosis Centre, Epworth HealthCare, Victoria, Australia.
概括
包括18F-FDG PET在内的正子发射断层扫描 (PET) 扫描显示,对诊断子宫内膜异位症的可靠性有限. 需要进一步的研究来探索其他PET标记物,以改善这种情况的检测和监测.
科学领域:
- 妇科瘤学 妇科瘤学
- 诊断成像 诊断成像 诊断成像
- 核医学是一种核医学.
背景情况:
- 子宫内膜异位症在全球范围内对妇女产生重大影响,但诊断往往会延迟,监测方法不够理想.
- 在子宫内膜病变中已经注意到18F-FDG PET标记物的偶然摄取,但其诊断效用仍然不清楚.
研究的目的:
- 对用于检测和监测子宫内膜异位症的PET扫描技术的现有证据进行系统审查.
- 确定当前PET成像模式在诊断和管理子宫内膜异位症中的价值.
主要方法:
- 进行了对MEDLINE,EMBASE,CENTRAL,SCOPUS和Web of Science数据库的系统审查.
- 包括涉及已知或疑似患有子宫内膜异位症的参与者,接受PET扫描的研究,不论标记物或协议.
- 评估的结果包括PET标记物摄入与腹腔镜/组织学发现的相关性,灵敏度,特异性,病变部位,阶段,SUVmax和不良事件.
主要成果:
- 包含了8项与110名参与者的研究;六项使用18F-FDG PET-CT,一项仅使用18F-FDG PET,一项使用68Ga-DOTATATE PET-CT.
- 对于18F-FDG成像,PET狂热与子宫内膜异位症的相关性在0-55%之间.
- 在手术前的68Ga-DOTATATE PET-CT检测出了33%的子宫内膜异位症;它的实用性仍然不确定.
结论:
- 18F-FDG PET扫描不能始终识别子宫内膜病变,这限制了其对子宫内膜异位症诊断的可靠性.
- 68Ga-DOTATATE PET-CT对子宫内膜异位症的有效性需要进一步研究.
- 有限的证据需要对其他具有生物可信性的PET标记物进行进一步的研究,以检测和监测子宫内膜异位症.
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