核和轨道前皮层的相差-振幅合反映了在延迟折扣任务期间的决策
V H Azocar1, P Petersson2, R Fuentes3
1School of Pharmacy and Interdisciplinary Center of Neuroscience, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de Chile, Chile; Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
大脑连接模式,特别是轨道前皮层 (OFC) 和内核 (NAc) 中的阶段幅度合 (PAC),区分冲动选择和自我控制. 在OFC和NAc中较高的delta-gammaPAC预测了冲动性决策.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 行为经济学是一种行为经济学.
背景情况:
- 冲动选择涉及更喜欢即时的奖励,而不是更大的,延迟的奖励.
- 冲动性的神经机制涉及到体核 (NAc),轨道前皮层 (OFC) 和背侧条纹体 (DLS).
- 功能连接在区分冲动与自我控制决策中的作用尚不清楚.
研究的目的:
- 在延迟折扣任务期间,调查NAc,OFC和DLS之间和内部的功能连接差异.
- 确定神经活动的特定模式是否区分冲动选择的高低倾向.
主要方法:
- 在延迟折扣任务期间,在NAc,OFC和DLS中同时记录小鼠的本地现场潜力.
- 在振荡活动之间量化相振幅合 (PAC),连贯性和格兰杰因果关系.
- 在具有高 (HI) 和低 (LI) 冲动选择倾向的老鼠中比较神经活动.
主要成果:
- 在OFC和NAc中观察到不同的PAC模式,但在决策过程中没有DLS.
- 在OFC中,theta-gamma PAC与自我控制相关;在OFC和NAc中,较高的delta-gamma PAC与冲动选择相关.
- 在奖励事件中,格兰杰因果关系显示HI组的NAcOFC马贡献和LI组的OFCNAc马贡献更强.
结论:
- 在高冲动性组的奖励期间,NAc中的过度活动表明其核心有助于奖励过高估值.
- 功能连接的改变,特别是OFC和NAc中的delta-gammaPAC,是偏见冲动行为的基础.
- 这些发现阐明了神经支区分冲动选择和自我控制.
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