在听觉中脑的声音和动作的混合表示
Gunnar L Quass1, Meike M Rogalla1, Alexander N Ford1
1Department of Otolaryngology-Head & Neck Surgery, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109.
概括
在下 (IC) 中的听觉中脑神经元共同代表任务期间的感官线索,行为和结果. 这种神经代码甚至在行为发生之前就预测了行为选择.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 将感官输入与行为后果联系起来,对大脑功能至关重要.
- 新皮质和边缘系统表现出"混合表示",整合了感官和任务变量.
- 这种融入皮层下听力通路的程度尚不清楚.
研究的目的:
- 在行为过程中调查听觉中脑中的整合计算.
- 为了确定下结核 (IC) 神经元是否代表传感,动作和结果变量的联合代码.
- 探索听觉中脑在复杂的听觉任务中的作用.
主要方法:
- 细胞分辨率的双光子成像在小鼠下层 (IC) 的表面层.
- 行为范式:固定头部的小鼠执行基于奖励的心理测量听觉任务.
- 对与听觉线索,行为和试验结果相关的神经群体活动的分析.
主要成果:
- 个体外IC神经元表现出反映听觉线索,鼠标行为和任务结果的活动.
- 神经群活动轨迹因老鼠的行为选择而异.
- 在预动神经活动上训练的分类器模型可以预测试验结果.
结论:
- 在IC中的听觉中脑神经元编码了声音,动作和任务依赖变量的联合表示.
- IC有助于整合感官信息与行为背景和结果.
- 听觉中脑中的这个人口代码支持复杂的听觉引导行为.
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