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Updated: Jun 23, 2025

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
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通过冷EM和SEC方法对肺炎球菌合疫苗6A血清型激活的量化和表征

Mingxiang Lin1, James Z Deng2, Giovanna Scapin3

  • 1Analytical Research & Development, Merck & Co., Inc., Rahway, NJ 07065, USA.

Vaccine
|June 25, 2024
PubMed
概括

为肺炎球菌合疫苗 (PCV) 开发新的分析方法可以确保更好的质量控制. 这些方法的特点是多糖激活,这是疫苗制造的关键步骤,用于一致的产品交付.

关键词:
冷电子显微镜 (Cryo-EM) 是一种电子显微镜.黄金纳米粒子 (AuNP) 标签肺炎球菌囊型多糖化物6A肺炎球菌结合疫苗的结合疫苗尺寸排除色谱 (SEC) 是一种尺寸排除色谱.

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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