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出生体重和肥胖之间的相互作用,决定了儿童和青少年心脏代谢风险
Sara Elizabeth Stinson1, Pauline Kromann Reim1, Morten Asp Vonsild Lund2
1Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
EBioMedicine
|June 25, 2024
概括
低出生体重 (BW) 和多基因BW分数与年轻人的心脏代谢风险有关. 儿童肥胖症加剧了这些关联,突出了针对性预防策略的需要.
科学领域:
- 儿科 儿科 儿科
- 遗传学 遗传学 是一个
- 代谢健康 代谢健康
背景情况:
- 出生体重 (BW) 是已知的成人心脏代谢性疾病 (CMD) 的风险因素.
- 儿童肥胖可能会加剧BW和未来健康风险之间的联系.
- 对BW在心脏代谢风险中的遗传倾向的作用需要进一步研究.
研究的目的:
- 研究儿童和青少年出生体重 (BW) 与心脏代谢风险之间的关联.
- 探索BW的多基因分数 (PGS) 与心脏代谢风险之间的关联.
- 为了确定儿童肥胖是否会改变这些关联.
主要方法:
- 对4263名儿童和青少年 (平均年龄11.7岁) 的横截面研究.
- 数据收集包括出生体重,人体测量,心脏代谢风险因素和血蛋白.
- 分析涉及多个线性回归和相互作用分析,以评估儿童肥胖的影响.
主要成果:
- 无论是BW还是BW的PGS都与心脏代谢风险和血蛋白水平有关.
- 儿童肥胖症显著改变了BW与胰岛素抵抗 (HOMA-IR,c-) 和血压 (SBP SDS) 的测量之间的关联.
- 儿童肥胖也改变了BW和14种血蛋白之间的关联.
结论:
- 低出生体重与年轻人的不良代谢表型有关,特别是胰岛素耐药性和高血压.
- 这些关联在肥胖儿童中更为明显.
- 针对性预防和治疗策略对于低体重和肥胖儿童至关重要,以减轻未来的CMD风险.
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