在结核病患者中测量异化,使用指汗与肌素正常化:一项受控剂量研究
K Longman1, O W Akkerman2, S Ghimire3
1School of Chemistry and Chemical Engineering, University of Surrey, Guildford, United Kingdom.
International journal of antimicrobial agents
|June 25, 2024
概括
指汗检测提供了一种方便的方法来监测结核病 (TB) 药物坚持和治疗药物监测 (TDM). 这种非侵入性方法可以准确检测异化水平,有助于治疗成功.
科学领域:
- 药理动力学 药理动力学
- 分析化学 分析化学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 对抗结核病 (TB) 药物的不良坚持有助于治疗失败和耐药性.
- 使用血液或唾液的治疗药物监测 (TDM) 有助于评估坚持性和剂量调整.
- 指汗检测为患者监测提供了一个非侵入性的替代方案.
研究的目的:
- 为了评估手指汗水测试的可行性,以检测药物坚持.
- 评估手指汗液分析作为TDM的半定量工具.
- 建立一种用于监测抗结核病药物水平的新方法.
主要方法:
- 十名患者接受了受控剂量的异化.
- 用手指的汗水,血液和唾液样本在药物注射后被采集.
- 液体染色学-质谱学用于样本分析.
主要成果:
- 在服用后1-6小时内,可以在指汗液中检测到异化物.
- 在汗水中将异化物正常化为肌氨酸,改善了与血清度的相关性.
- 这种规范化方法可以考虑样本体积的变化.
结论:
- 这项研究表明,在指汗中测量了异化的时间流程,与血液水平相关.
- 指汗中的药物与肌素的比率提供了一个可行的TDM方法.
- 这种可适应的技术可以提高患者体验,减少临床工作量.
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