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Updated: Jun 23, 2025

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging
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对冷干燥制药结构缺陷的自动断层评估

Patric Müller1, Achim Sack1, Jens Dümler1

  • 1Institut für Multiskalensimulation, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

AAPS PharmSciTech
|June 25, 2024
PubMed
概括

使用机器人,计算机断层扫描和机器学习对冷干燥制药的自动检查确保了产品的质量. 这种非破坏性方法增强了稳定性和可重组性评估,改善了制药制造.

关键词:
射线断层扫描X射线断层扫描在冷干燥过程中进行冷干燥.解化酸盐的使用方法非破坏性检查是非破坏性检查.

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Electron Microscope Tomography and Single-particle Reconstruction01:07

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
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