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Updated: Jun 23, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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最近的多个HCAR2结构显示出高度动态的带结合和G蛋白激活模式

Aslihan Shenol1, Ricardo Tenente1, Michael Lückmann1

  • 1Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Nature communications
|June 25, 2024
PubMed
概括

三十个新的3D结构揭示了氧碳酸受体2 (HCAR2) 的全性机制. 激动剂结合方式类似,尽管副作用,突出需要进一步的分子动力学研究.

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